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ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress
ScienceDirect.com
Oxidative stress-induced autophagy helps to prevent cellular damage and to maintain homeostasis. However, the regulatory pathway that...
4 miesiące temu
CHEK2 is a potential prognostic biomarker associated with immune infiltration in clear cell renal cell carcinoma ...
Nature
Checkpoint kinase 2 (CHEK2) plays a crucial role in responding to DNA damage and is linked to diverse cancer types.
4 miesiące temu
Chk2 inhibitor found to modulate insulin secretion and glucose metabolism
BioWorld MedTech
After an initial chemical screening, researchers at the University of Pennsylvania and Weill Cornell Medicine identified the Chk1/Chk2 dual...
5 miesięcy temu
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?
Nature
CHK2, an important player in the DNA-damage response signalling pathway, is a candidate multiorgan tumour susceptibility gene. Will the targeted modulation...
74 miesiące temu
Arum Therapeutics divulges new Chk2 inhibitors for cancer
BioWorld MedTech
Arum Therapeutics Inc. has synthesized checkpoint kinase 2 (Chk2) inhibitors reported to be useful for the treatment of cancer.
6 miesięcy temu
Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest | Oncogenesis
Nature
CHK1 and CHK2 are both activated upon DNA damage and can regulate cell division. CHK1 activity has been mostly implicated in the intra-S phase...
49 miesięcy temu
Aurora-A controls cancer cell radio- and chemoresistance via ATM/Chk2-mediated DNA repair networks
ScienceDirect.com
Highlights. •. Aurora-A and BRCA1/2 are mutually suppressed in cancer cells. •. Aurora-A and BRCA1/2 inversely control cancer cell radio- and chemo-resistance.
76 miesięcy temu
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 ...
Nature
Radiotherapy is the backbone of nasopharyngeal carcinoma (NPC), nearly 11–17% NPC patients suffered local relapse and 18–37% suffered...
10 miesięcy temu
JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability | Cell ...
Nature
Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the...
21 miesięcy temu
SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation | Cell Death & Differentiation
Nature
Both the stress-response protein, SIRT1, and the cell cycle checkpoint kinase, CHK2, play critical roles in aging and cancer via the...
58 miesięcy temu