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Targeting IL-17A enhances imatinib efficacy in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia

Nature
The cytokine IL-17A, derived from Th17 cells, promotes Ph+ B-ALL progression and increases CXCL16 expression in leukemia cells. The increased...
3 miesiące temu

Frontline Combination of Ponatinib and Hyper-CVAD in Philadelphia Chromosome-Positive Acute Lymphoblastic ...

Cancer Network
Experts provide extended follow-up on efficacy and safety outcomes with initial therapy combining ponatinib and hyperfractionated...
miesiąc temu

The Philadelphia Chromosome, circa 1960

The Scientist Magazine
By Cristina Luiggi The Philadelphia Chromosome, circa 1960 Related Articles New Smoking Gun? Cancer Genetics Gets Personal New Medicine Means Research...
2 miesiące temu

Takeda's Iclusig wins first-line FDA nod to treat rare Philadelphia chromosome-positive ALL

Fierce Pharma
The FDA has approved Takeda's Iclusig for use plus chemotherapy for newly diagnosed, first-line patients with Philadelphia chromosome ALL.
miesiąc temu

Episode 5: Monitoring and Diagnostics in Chronic Myeloid Leukemia

Medscape
Drs Michael J. Mauro and Jerald P. Radich discuss monitoring and diagnostics in chronic myeloid leukemia, including the Philadelphia...
6 miesięcy temu

Ph+ CML: What's Different in the United States? And Why? - Chronic Myeloid Leukemia in Adults

MedPage Today
In Europe, patients with Philadelphia chromosome-positive CML generally have better rates of survival than similar patients in the U.S....
tydzień temu

Study Discovers a Mechanism for Genetic Changes in Therapy-Induced Leukemia, Builds on Fox Chase History of ...

Fox Chase Cancer Center
PHILADELPHIA (October 2, 2023) — In a recent study, researchers at Fox Chase Cancer Center demonstrated how amplification and rearrangement...
6 miesięcy temu

Defining and Diagnosing Philadelphia Chromosome-Positive (Ph+) ALL

OncLive
Amanda Przespolewski, DO, and Ibrahim Aldoss, MD define and discuss how to diagnose patients with Ph+ALL.
9 miesięcy temu

ALL in Adults: Trial Updates and Clinical Considerations for Selecting Consolidation Therapy

The ASCO Post
Although pediatric patients with acute lymphoblastic leukemia (ALL) have seen a dramatic improvement in long-term survival rates over the...
2 miesiące temu

Newly Diagnosed Ph+ CML Derives MMR Benefits With Asciminib vs SOC TKIs

Oncology Nursing News
Treatment with asciminib for newly diagnosed, Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase induced...
3 miesiące temu