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Specific pharmacological and Gi/o protein responses of some native GPCRs in neurons
Nature
G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins and are important drug targets.
miesiąc temu
Stimulation of Cannabinoid Receptor CB1 Induces krox-24 Expression in Human Astrocytoma Cells
ScienceDirect.com
The recent isolation and cloning of the G protein-coupled central cannabinoid receptor (CB1) from brain tissue has provided a molecular basis to elucidate...
39 miesięcy temu
The synthetic CB1 cannabinoid receptor selective agonists: Putative medical uses and their legalization
ScienceDirect.com
More than 500 molecules have been identified as components of Cannabis sativa (C. sativa), of which the most studied is Δ9-tetrahydrocannabinol (Δ9 -THC).
37 miesięcy temu
Part 1 exploring how marijuana alters brain function: the mechanism.
Psychology Today
Around 4 percent of adults worldwide smoked cannabis at least once in the last year according to a United Nations study.
116 miesięcy temu
CBD Oil For Dental Pain? Maybe | American Council on Science and Health
American Council on Science and Health |
A small, but well-conducted, study of the effect of CBD oil on bad toothaches neither proves nor disproves whether the drug works.
3 miesiące temu
In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies ...
Nature
G protein-coupled receptors (GPCRs) are important signal transducers that are phosphorylated upon activation at intracellular serine and...
12 miesięcy temu
Endogenous and synthetic cannabinoids induce the downregulation of cannabinoid CB1 receptor in retina
ScienceDirect.com
Endogenous and synthetic cannabinoids have been shown to provide neuroprotection to retinal neurons in acute animal models of retinopathy.
46 miesięcy temu
Thermostability of a recombinant G protein-coupled receptor expressed at high level in mammalian cell culture ...
Nature
Rational design of pharmaceutical drugs targeting integral membrane G protein-coupled receptors (GPCR) requires thorough understanding of...
42 miesiące temu
Cannabinoid Receptor Agonist - an overview
ScienceDirect.com
Khalil Eldeeb, ... Allyn C. Howlett, in Methods in Enzymology, 2017. 5 Summary and Conclusion. Our investigations demonstrate that in N18TG2 neuroblastoma...
46 miesięcy temu
Chronic Δ9-Tetrahydrocannabinol During Adolescence Provokes Sex-Dependent Changes in the Emotional Profile in ...
Nature
Few and often contradictory reports exist on the long-term neurobiological consequences of cannabinoid consumption in adolescents.
195 miesięcy temu