... CP 55,940, and reported favorable incubation conditions for a binding assay with this radiolabeled ligand [103] ... CP 55,940 binding in brain is predominately, if not exclusively, to the CB1 receptor. Howlett et al. [104] found an ...
... CP 55940 and antagonist SR 141716A . ( A ) Current recordings to voltage steps from -50 mV to +35 mV in 14 mV steps illustrating the reversible suppression of IK ( v ) by 1 μM CP 55940 and the blockade of this suppression by lμM SR ...
... CP 55,940 and HU-210 failed to compete with [3H]WIN 55212-2. Only WIN 55212-2 could induce activity with the mutated receptor (Song and Bonner, 1996). Similar results with CP 55,940 and WIN 55212-2 were obtained with K192L, K192Q and ...
... CP-55940 (3H-6), a centrifugation binding assay was developed that identified and characterized a cannabinoid receptor in rat brain.15 Since the receptor is coupled to a G-protein, its affinity for cannabinoid drugs can be modulated by ...
... ( CP - 55,940 ) . OH OH A. THC m OH CP - 55,940 The structural differences between the naturally occurring cannabinoid delta - 9- tetrahydrocannabinol ( A9 - THC ) , and this synthetic agent are quite dramatic , yet this compound has been ...
... ( CP - 55,940 ) . OH OH - THC OH CP - 55,940 The structural differences between the naturally occurring cannabinoid delta - 9- tetrahydrocannabinol ( A9 - THC ) , and this synthetic agent are quite dramatic , yet this compound has been ...
... CP-55,940, while decreased that of rimonabant.40,193 However, in cellular functional assays, Org27569 decreased G protein-coupling induced by CP-55,940194 more, and promoted Org27569 showed orthosteric internalization ligand-dependent ...
... CP - 55940 binding at this receptor . [ H ] CP - 55940 binding is also found in the nervous systems of lower vertebrate species . The cannabinoid receptor appears to be conserved across species in that the K values are similar , and the ...
... CP - 55,940 , a potent bicyclic cannabinoid , to several sites in the PAG would produce any behavioral effects in rats . In order to ascertain whether the effects were stereoselective CP - 56,667 , the inactive stereoisomer of CP - 55,940 ...
... CP-55,940. Substitution was specific for cannabinoids since several drugs from other classes (phencyclidine, haloperidol and diazepam) failed to elicit responding on the CP-55,940-appropriate lever [73]. Also, JWH-018 and JWH-073, two ...