CHEK2 - Wikipedia
WEBCHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to …
What is CHEK2? | Dana-Farber Cancer Institute
WEBAug 27, 2019 · Updated: November 8, 2023. Medically Reviewed By: Huma Q. Rana, MD, MPH. Key Takeaways: CHEK2 is a tumor-suppressor gene that protects cells from becoming cancerous. People who inherit mutations in the gene are at increased for certain types of cancer and may benefit from more frequent screening.
CHK2 kinase in the DNA damage response and beyond - PMC
WEBNov 17, 2014 · In this review, we discuss the activity of CHK2 in response to DNA damage and in the maintenance of the biological functions in unstressed cells. These activities are also considered in relation to a possible role of CHK2 in tumorigenesis and, as a consequence, as a target of cancer therapy.
CHK2 kinase: cancer susceptibility and cancer therapy - Nature
WEBMetrics. Key Points. CHK2 is a versatile and multifunctional kinase that regulates the cell's response to DNA damage by phosphorylating a number of distinct cellular substrates. CHK2 can...
CHEK2 is a potential prognostic biomarker associated with
WEBDec 11, 2023 · Checkpoint kinase 2 (CHEK2) plays a crucial role in responding to DNA damage and is linked to diverse cancer types. However, its significance in the prediction of prognosis and impacts on...
Chk2 kinase — a busy messenger | Nature Reviews Molecular Cell Biology
WEBDec 1, 2001 · Checkpoint kinase 2 (Chk2) is emerging as a key mediator of diverse cellular responses to genotoxic stress, guarding the integrity of the genome throughout eukaryotic evolution.
Current perspectives on CHEK2 mutations in breast cancer
WEBMay 12, 2017 · Checkpoint kinase 2 (CHEK2) is a serine/threonine kinase which is activated upon DNA damage and is implicated in pathways that govern DNA repair, cell cycle arrest or apoptosis in response to the initial damage. Loss of kinase function has been correlated with different types of cancer, mainly breast cancer.
CHK2 kinase in the DNA damage response and beyond - PubMed
WEBIn human cells, following genotoxic stress, CHK2 is activated and phosphorylates >20 proteins to induce the appropriate cellular response, which, depending on the extent of damage, the cell type, and other factors, could be cell cycle checkpoint activation, induction of apoptosis or senescence, DNA repair, or tolerance of the damage.
The Chk2 protein kinase - PubMed
WEBCheckpoint kinase 2 (Chk2) is a multifunctional enzyme whose functions are central to the induction of cell cycle arrest and apoptosis by DNA damage. Insight into Chk2 has derived from multiple approaches. Biochemical studies have addressed Chk2 structure, domain organization and regulation by phosphorylation.
About Mutations in the CHEK2 Gene - Memorial Sloan Kettering Cancer Center
WEBJul 17, 2023 · A CHEK2 gene mutation increases your risk for certain types of cancers. Your cancer risk may be different depending on the specific CHEK2 mutation you have. Most CHEK2 mutations increase your risk for breast cancer.
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