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    Ciclosporin - Wikipedia

    Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, eczema, and in organ transplants to prevent rejection. It is also used as eye drops … See more

    Ciclosporin is indicated to treat and prevent graft-versus-host disease in bone marrow transplantation and to prevent rejection of kidney, … See more

    Mechanism of action
    Ciclosporin's main effect is to lower the activity of T-cells; it does so by inhibiting calcineurin in … See more

    Cyclosporin is synthesized by a nonribosomal peptide synthetase, cyclosporin synthetase. The enzyme contains an adenylation domain, a thiolation domain, a … See more

    Neuroprotection
    Ciclosporin is in a phase II/III (adaptive) clinical study in Europe to determine its ability to ameliorate… See more

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    Overview image

    In 1970, new strains of fungi were isolated from soil samples taken from Norway and from Wisconsin in the US by employees of Sandoz (now Novartis) in Basel, Switzerland. Both strains … See more

    Name
    The natural product was named cyclosporin by the German-speaking scientists who first … See more

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  2. Cyklosporyna - Medycyna Praktyczna

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  4. Cyclosporin A - an overview | ScienceDirect Topics

  5. Functional evaluation of cyclosporine metabolism by CYP3A4 …

  6. cyclosporin A | C62H111N11O12 | CID 5284373

    webcyclosporin A | C62H111N11O12 | CID 5284373 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and …

  7. Cyclosporin A …

  8. CYSPR - Overview: Cyclosporine, Blood - Mayo Clinic Laboratories

  9. Treatment of atopic dermatitis with cyclosporin A: A …

    webSep 1, 2017 · One of the immunosuppressants is cyclosporine A. Initially, cyclosporine was used as an antifungal drug, but later in the course of research it turned out to be a drug with strong immunosuppressive...

  10. A Comparison of Tacrolimus (FK 506) and Cyclosporine …

    webOct 27, 1994 · Most immunosuppressive regimens for liver transplantation are based on cyclosporine. Methods. We conducted an open-label, randomized, multicenter trial to compare the efficacy and safety of...