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Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma
Nature
Hepatoblastomas (HB) display heterogeneous cellular phenotypes that influence the clinical outcome, but the underlying mechanisms are poorly...
miesiąc temu
When the Belly Looks Okay but Is Actually Not: A Case of Hepatoblastoma in a Well-Appearing Child
Cureus
Hepatoblastoma is one of the pediatric tumors with genetic and intrauterine risk factors. It is typically asymptomatic at diagnosis,...
5 dni temu
A promising new treatment strategy for hepatoblastoma
Drug Target Review
A combination therapy of vincristine, irinotecan and panobinostat, tested in high-risk, relapsed or refractory HB spheroids,...
3 miesiące temu
Novel combination therapy offers promising results for treatment-refractory hepatoblastoma
Baylor College of Medicine | BCM
Identifying an effective new combination therapy. First, the researchers tested several HDAC inhibitors on their ability to kill patient-derived...
3 miesiące temu
Potential targets to treat hepatoblastoma identified • healthcare-in-europe.com
healthcare-in-europe.com
Hepatoblastoma is the most frequent liver cancer in childhood. Despite the advances in its combined treatment involving surgery and...
7 miesięcy temu
What Are the Best Hospitals in the USA for Hepatoblastoma Treatment in Pediatrics?
Medical Tourism Magazine
Top Hospitals in the USA for Hepatoblastoma Treatment · Children's Hospital of Philadelphia (CHOP) · Dana-Farber/Boston Children's Cancer and Blood Disorders...
5 miesięcy temu
Rare liver cancer found in toddler with Alagille syndrome
Liver Disease News
A case report describes a toddler with cirrhosis due to Alagille syndrome diagnosed with hepatoblastoma, a cancer thought rare in Alagille.
3 tygodnie temu
Preneoplastic liver colonization by 11p15.5 altered mosaic cells in young children with hepatoblastoma
Nature
We show that mosaic 11p15.5 alterations in liver FFPE sections of hepatoblastoma patients display IGF2 overexpression and H19 downregulation...
7 miesięcy temu
Revolutionizing Pediatric Oncology: New Combination Therapy for Hepatoblastoma Shows Promise
Medriva
Most notably, the therapy integrates an HDAC inhibitor called panobinostat with vincristine and irinotecan. This strategic combination has...
3 miesiące temu
A novel treatment strategy utilizing panobinostat for high-risk and treatment-refractory hepatoblastoma
ScienceDirect.com
Patients with treatment-refractory hepatoblastoma have limited treatment options with survival rates of less than 50%. Our manuscript demonstrates that...
4 miesiące temu