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Design and synthesis of indol-2-one derivatives as potential RET inhibitors
ScienceDirect.com
In summary, we designed and synthesized five series of indol-2-one derivatives as novel RET kinase inhibitors. During the optimization process,...
5 miesięcy temu
Synthesis, docking, MD simulation, ADMET, drug likeness, and DFT studies of novel furo[2,3-b]indol-3a-ol as promising ...
Nature
A new series of furo[2,3-b]indol-3a-ol derivatives was synthesized to investigate their potential as inhibitors of the Cyclin-dependent...
3 miesiące temu
Synthesis, in vitro Α-Glucosidase, and acetylcholinesterase inhibitory activities of novel Indol-Fused Pyrano[2,3-D ...
ScienceDirect.com
Highlights. •. New indol-fused pyrano-[2,3-d]pyrimidines 11a-l were designed and synthesized. •. The plausible mechanism for formation of...
4 miesiące temu
Identification of (E)-1-((1H-indol-3-yl)methylene)-4-substitute-thiosemicarbazones as potential anti-hepatic fibrosis agents
ScienceDirect.com
Liver fibrosis remains a global health challenge due to its rapidly rising prevalence and limited treatment options. The orphan nuclear receptor Nur77 has...
5 miesięcy temu
The fate of vegetable and endogenous indoles in our body
EurekAlert!
image: LTr1 and DIM form as antitumor agents in mouse gastrointestinal tract from cruciferous vegetable-derived indole-3-carbinol (I3C).
31 miesięcy temu
Facile synthesis of bis(indol-3-yl)methane derivatives catalyzed by carboxylic acid functionalized ionic liquid at room ...
ScienceDirect.com
These reactions are particularly notable for their utility in the synthesis of bis(indolyl)methanes (BIM) and trisindolines [17]. The conventional approach...
4 miesiące temu
Europium(III) Ion-Based photoluminescence complexes of Indole-Derivative β-diketone dominated by ancillary ligands
ScienceDirect.com
One pot reaction of β-diketone EIFD, EuCl3·6H2O and ancillary ligand yields a series of β-diketone europium complexes.
8 miesięcy temu
Synthesis, characterization and biological investigations of some new Oxadiazoles: In-vitro and In-Silico approach
ScienceDirect.com
A series of new oxadiazole derivatives, namely 1-{2-substituted phenyl −5-[2-tifluoromethyl)-1H-indol-3-yl]-3-(2H)-ylethanone 1,3,4-oxadiazoles were...
6 miesięcy temu
Erythrinoid and indol alkaloids isolated from the seeds of Erythrina rubrinervia Kunth: Chemotaxonomic significance
ScienceDirect.com
Four of the isolated alkaloids are erythrinoid type alkaloids which were identified as erysodine (1), erysovine (2), erythraline (3) and erysotrine (4), plus an...
11 miesięcy temu
Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative ...
ScienceDirect.com
The advantages of topically applied CIM for treating psoriasis are the targeting of multiple signalings, facile absorption into the skin, and ease of...
56 miesięcy temu