A substantial and positive association was found in this study between IL-12 and IL-4 blood levels and the Ham-D scores of MDD patients. This...
3 miesiące temu

1. In this cohort study, neutralizing autoantibodies against interleukin-23 (anti-IL-23) were associated with severe,...
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Interleukins are secreted proteins that regulate immune responses. Among these, the interleukin 12 (IL-12) family holds a central position...
6 miesięcy temu

RT-111 achieved high bioavailability in humans - - RT-111 was well-tolerated, with no serious adverse events - - Celltrion has right of...
3 miesiące temu

Human natural killer T cells (NKTs) are innate-like T lymphocytes increasingly used for cancer immunotherapy. Here we show that human NKTs...
4 miesiące temu

Original Article. Phase I trial of oncolytic adenovirus-mediated cytotoxic and interleukin-12 gene therapy for the treatment of metastatic pancreatic cancer.
41 miesięcy temu

Pembrolizumab Plus Interleukin-12 Shows Activity in Metastatic Melanoma ... "Combining pembrolizumab with Tavo electroporation improved responses...
48 miesięcy temu

Chimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited T cell trafficking, persistence, and durable anti-tumor...
9 miesięcy temu

Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that induces the production of interferon-γ (IFN-γ), favours the...
255 miesięcy temu

We describe a strategy to block the signalling activity of IL-12 by masking the receptor binding site of IL-12 with a fused receptor domain,...
24 miesiące temu