Tran et al. found that IL-18 in the stomach is predominantly produced by epithelial cells in response to H. pylori, and this epithelial IL-18...
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Highlights. •. IL-18 can boost innate and adaptive anticancer immune responses. •. IL-18 as a monotherapy agent has shown poor anticancer effectiveness. •.
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Deals between major cancer cell therapy players and biotechs with strategies to promote IL-18 signaling unhampered by decoy receptors...
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Although preclinical studies of genetically engineered interleukin-18 (IL-18) historically indicated its potential in cancer treatment,...
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NOD1 activation and IL-18 then help maintain epithelial homoeostasis to mediate protection against pre-neoplastic changes induced by gastric H.
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Simcha Therapeutics (CT, USA) partners with Janssen Biotech (CA, USA) to enhance CAR T-cell therapies using its IL-18 technology.
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Interleukin-18 (IL-18) has emerged as a potent anticancer immunostimulatory cytokine over the past three decades. IL-18, structurally is a...
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Gilead's deal for Compugen's IL-18 program will give the biotech a cash lifeline that could grow stronger as the antibody moves toward an...
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IL-37 is a newly discovered member of the IL-1 cytokine family which plays an important role in regulating inflammation and maintaining physiological...
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The current report describes a stepwise mechanistic pathway of NLRP3/caspase1/IL-18-regulated immune responses operational in eosinophilic...
9 miesięcy temu