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The role of TSC1 and TSC2 proteins in neuronal axons | Molecular Psychiatry
Nature
Tuberous Sclerosis Complex 1 and 2 proteins, TSC1 and TSC2 respectively, participate in a multiprotein complex with a crucial role for the...
4 miesiące temu
The Role of TSC1 in Liver Ischemia/Reperfusion Injury and its Correlation with Liver Macrophages
Medriva
Recent research has highlighted the crucial role of the TSC1 gene in liver I/R injury and its potential therapeutic implications.
3 miesiące temu
Loss of macrophage TSC1 exacerbates sterile inflammatory liver injury through inhibiting the AKT/MST1/NRF2 ...
Nature
Tuberous sclerosis complex 1 (TSC1) plays important roles in regulating innate immunity. However, the precise role of TSC1 in macrophages in...
3 miesiące temu
Aadi Bioscience Announces Poster Presentations at 2023 AACR-NCI-EORTC International Conference on Molecular ...
PR Newswire
Two new real-world next-generation sequencing studies reinforce prevalence of TSC1/2 mutations in up to 2% of all tumors, a significant...
7 miesięcy temu
Cobalt induces neurodegeneration through FTO-triggered autophagy impairment by targeting TSC1 in an m6A ...
ScienceDirect.com
Author links open overlay panel. Jianping Tang a b 1 , Fuli Zheng a b c 1 , Xu Liu a b , Yanjun Li a b , Zhenkun Guo a b , Xinpei Lin a b
10 miesięcy temu
Dr. Schulte on the Prevalence of TSC1/TSC2 Mutations in Cancer
OncLive
TSC1/2 mutations are pathogenic mutations that are seen in a variety of histologic subtypes and malignancies, but the prevalence of the mutation...
18 miesięcy temu
Cobalt induces neurodegeneration through FTO-triggered autophagy impairment by targeting TSC1 in an m6A ...
ScienceDirect.com
Cobalt is the most widely used heavy metal pollutant in medicine and industry. Excessive cobalt exposure can adversely affect human health.
10 miesięcy temu
Dr. Schulte on the PRECISION 1 Trial of Nab-Sirolimus in TSC1/2-Mutated Solid Tumors
OncLive
Brian Schulte, MD, discusses the ongoing phase 2 PRECISION 1 basket trial evaluating the use of nab-sirolimus for adult and adolescent...
15 miesięcy temu
Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons
Nature
Here, we show that conditional loss of the Tuberous Sclerosis Complex (TSC) gene, Tsc1, which inhibits the mammalian target of rapamycin (MTOR),...
54 miesiące temu
TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
ScienceDirect.com
TSC1 is required for lysosomal recruitment of TSC2, and blocking PI3,5P2 synthesis in cells by knockdown or pharmacological inhibition of...
34 miesiące temu