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CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma | Cell Death Discovery
Nature
Results · CHEK2 could be a potential drug target for HCC · Knockout of CHEK2 selectively induces proliferation arrest, cell cycle blockade, and...
3 miesiące temu
International workgroup of geneticists issues CHEK2 guidelines - VUMC News
VUMC News
Inherited CHEK2 mutations have been linked to raised risks of breast cancer, colorectal cancer, and prostate cancer. But CHEK2 is largely...
9 miesięcy temu
Germline CHEK2 mutations in patients with myeloid neoplasms | Leukemia
Nature
An important observation of our study is that CHEK2mutGL patients do not seem to exhibit a younger age of onset for myeloid malignancies or a...
2 miesiące temu
Guidance on clinical management of CHEK2 pathogenic variants and cancer risks
Medical Xpress
Guidance on clinical management of CHEK2 pathogenic variants and cancer risks ... A person with a pathogenic variant in the CHEK2 gene may be at...
9 miesięcy temu
Understanding the CHEK2 Mutation and its Impact on Myeloid Neoplasms: A Comprehensive Review
Medriva
CHEK2 Mutation and Myeloid Neoplasms. The CHEK2 gene plays a vital role in the body's response to DNA damage. When functioning correctly, it can...
2 miesiące temu
SABCS Studies Explore Germline Mutations' Varied Effects on Breast Cancer Risk, Survival Outcomes
Precision Medicine Online
Researchers examine the interplay of germline cancer risk mutations and somatic mutations, and how surgery type and contraceptives impact...
4 miesiące temu
Scientists discover evidence of 4 more breast cancer genes—and potentially many others: 'The risks can be significant ...
Fortune
Patients who are savvy about potential cancer-causing variants are able to better advocate for themselves when talking with their health...
8 miesięcy temu
Courageously Facing Hereditary Breast Cancer
Kaiser Permanente
Fay Gordon's breast cancer was caught in the early stages thanks to genetic testing. Learn more about Kaiser Permanente's hereditary cancer...
9 miesięcy temu
CHEK2 is a potential prognostic biomarker associated with immune infiltration in clear cell renal cell carcinoma ...
Nature
Checkpoint kinase 2 (CHEK2) plays a crucial role in responding to DNA damage and is linked to diverse cancer types.
4 miesiące temu
Carriers of CHEK2 Mutations Have a 2-Fold Increased Risk for Contralateral Breast Cancer, Says Expert
Cancer Network
What our study demonstrates is that CHEK2 mutation carriers are at an approximately two-fold increased risk of contralateral breast cancer,...
15 miesięcy temu