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... M2 - PK adapts energy - consuming cell proliferation and nutrient supply ( 1 , 2 ) . In tumor cells a high amount of the less active , dimeric form of M2 - PK is always found . Therefore , the dimeric form of M2 - PK has been termed Tumor ...
... tumor cells typically express a particular isoenzyme of pyruvate kinase called type M2 - PK . This isoenzyme exists in two different forms : the so - called tumor M2 - PK , which is strongly overexpressed in tumor cells , and the lung M2 - ...
... tumor M2-pyruvate kinase levels in patients with colorectal cancer. Turk J ... tumor progression in human biliary tract cancer. Cancer 119:575–585 Hardt PD, Ngoumou ... PK) concentrations in patients with gastric cancer, colorectal cancer ...
... M2 - PK is intimately connected to the regulation of PFK , which , as indicated earlier , depends on the levels of ... tumor cells . Important- ly , tumor cells expressing a mutant form of M2 - PK that is not capable of phosphotyrosine ...
... tumor M2 pyrurate kinase ( Tu - M2 - PK ) as a tumor marker in patients with pre- invasive ( CIN ) , invasive ( PCC ) and recurrent ( RCC ) cervical cancer . Plasma samples were investigated from 125 patients , comprising 50 cases of ...
... M2 - PK IP control IgG Anit - M2 - PK TEM8 - FC Fig . 3. Identification of the natural interacting partner for tumor endothelial marker 8 ( TEM8 ) . The homogenate of HepG2 tumors was pretreated with a protein A - Sepharose 4 Fast Flow ...
... M2 is a novel diagnostic marker and predicts tumor progression in human ... PK), which serves as the key regulator of cellular energy metabolism in ... M2-PK concentra- tions were measured by enzyme-linked immunosorbent assay in 88 ...
... tumor cells as well as cells under normal cell growth conditions have to ... M2 - type isoenzyme of pyruvate kinase is present in many tissues such as ... PK ) ( EC 2.7.1.40 ) . The M2 - PK itself can be transformed from a tetrameric into ...
... PK C Tumor M2-PK ATP I ] \~> ATP ppGOV-src ' GTP pyruvate HP\/_16 E7 pyruvate high PEP affinity low PEP affinity highly active Fig. 16.3 Regulation and metabolic consequences ofthe quaternary structures of MZ-PK. MZ-PK may occur in a ...
... tumor M2 pyruvate kinase as a diagnostic tool for colorectal cancer ... PK) concentrations in patients with gastric cancer, colorectal cancer ... M2 expression with tumor grade in non-small cell lung cancer. Anticancer Res 34 (7):3811 ...