... C75 reduced food intake and body weight after systemic and intracerebroventricular administration in mice (Loftus et al., 2000). Recently, it has been shown that chronic C75 treatment reduced food intake, adipose tissue mass and hepatic ...
... C75 (Kumar et al. 2002; Ronnett et al. 2005). Yet, not all findings support the assumption that hypothalamic malonyl-CoA levels are involved in the feeding-inhibitory effect of i.c.v. C75 (Wortman et al. 2003). In addition, some results ...
... C75 prior to cleavage under conditions used in these experiments is < 6.5 ( Gong et al . 2007 ; Nakano and Bevilacqua 2007 ) . C75 thus exists largely in the deprotonated , inactive state under the conditions used in those studies ...