What is CHEK2? | Dana-Farber Cancer Institute
WEBAug 27, 2019 · Updated: November 8, 2023. Medically Reviewed By: Huma Q. Rana, MD, MPH. Key Takeaways: CHEK2 is a tumor-suppressor gene that protects cells from becoming cancerous. People who inherit mutations in the gene are at increased for certain types of cancer and may benefit from more frequent screening.
CHEK2 - Wikipedia
WEBCHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to …
About Mutations in the CHEK2 Gene - Memorial Sloan Kettering Cancer Center
WEBJul 17, 2023 · A CHEK2 gene mutation increases your risk for certain types of cancers. Your cancer risk may be different depending on the specific CHEK2 mutation you have. Most CHEK2 mutations increase your risk for breast cancer. Some of the most common CHEK2 mutations slightly increase your risk for colorectal (colon and rectal) cancer.
Gene Mutation CHEK2 and Cancer Risk - Everyday Health
WEBAug 23, 2022 · Checkpoint kinase 2, or CHEK2, for short, is a gene that normally helps with DNA repair. If you have a mutation, or variation, in this gene, you may be at an increased risk for developing...
Information for People with an Inherited CHEK2 Mutation
WEBCancer Risks. Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited CHEK2 mutations. More info. Risk Management Options. Read about expert guidelines for cancer screening and prevention for people with a CHEK2 mutation.
CHEK2 Gene - GeneCards | CHK2 Protein | CHK2 Antibody
WEBApr 2, 2024 · CHEK2 (Checkpoint Kinase 2) is a Protein Coding gene. Diseases associated with CHEK2 include Tumor Predisposition Syndrome 4 and Prostate Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Homology Directed Repair.
11200 - Gene ResultCHEK2 checkpoint kinase 2 [ (human)]
WEBApr 16, 2024 · CHEK2 is involved in the DNA damage repair response Fanconi anemia (FA)-BRCA pathway. An increased risk for breast and other cancers has been documented in individuals who carry a single pathogenic CHEK2 variant. CHEK2 splicing variant c.793-1G > A is a deleterious variant.
WEB• The job of the CHEK2 gene is to prevent cancer. It is called a tumor suppressor gene. When working correctly, tumor suppressor genes help to prevent cancer by controlling the growth and division of cells.
CHK2 kinase: cancer susceptibility and cancer therapy - Nature
WEBCHK2 is a versatile and multifunctional kinase that regulates the cell's response to DNA damage by phosphorylating a number of distinct cellular substrates. CHK2 can prevent tumour progression...
CHEK2 is a potential prognostic biomarker associated with
WEBDec 11, 2023 · Checkpoint kinase 2 (CHEK2) plays a crucial role in responding to DNA damage and is linked to diverse cancer types. However, its significance in the prediction of prognosis and impacts on...
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