Transmembrane activator and CAML interactor - Wikipedia
WEBTransmembrane activator and CAML interactor ( TACI ), also known as tumor necrosis factor receptor superfamily member 13B ( TNFRSF13B) is a protein that in humans is encoded by the TNFRSF13B gene . TNFRSF13B is a transmembrane protein of the TNF receptor superfamily found predominantly on the surface of B cells, which are an …
TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated ... - PubMed
WEBThe discovery of TACI mutations associated with common variable immunodeficiency (CVID) in humans not only reinforces its important role for humoral responses but also suggests a more complex role than first anticipated from knockout animals. TACI is emerging as an unusual TNF receptor-like molecule with a sophisticated mode of action.
TACI deficiency — a complex system out of balance
WEBAug 1, 2021 · TACI regulates immune cell homeostasis, differentiation and function and is embedded in a complex network of cytokines, TNFSF ligands, microbial danger signals and its cognate receptors. TACI primarily serves as a receptor for BAFF (B cell activating factor) and APRIL (A proliferation inducing ligand) ( Figure 1 a).
BAFF: A fundamental survival factor for B cells - Nature
WEBJul 1, 2002 · BAFF is a trimeric membrane-bound or soluble factor that binds to three receptors — BCMA (B-cell maturation antigen), TACI (transmembrane activator and calcium-modulator and cyclophilin ligand...
TACI Isoforms Regulate Ligand Binding and Receptor Function
WEBOct 2, 2018 · TACI signals activate B cell proliferation, isotype switch and antibody production in both normal immunity and autoimmune states. In contrast to murine TACI, the human TACI gene undergoes alternative splicing …
Anti-TACI single and dual-targeting CAR T cells overcome BCMA …
WEBNov 18, 2023 · Here the authors describe the design of TACI-directed single and dual CAR T cells with in vitro and in vivo activity against multiple myeloma, overcoming BCMA antigen loss.
Transmembrane Activator and CAML Interactor (TACI): Another …
WEBApr 23, 2020 · Transmembrane Activator and CAML Interactor (TACI): Another Potential Target for Immunotherapy of Multiple Myeloma? - PMC. Journal List. Cancers (Basel) PMC7226350. As a library, NLM provides access to scientific literature.
APRIL signaling via TACI mediates immunosuppression by T
WEBPublished: 22 August 2018. Immunotherapy. APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications. Yu-Tzu Tai, Liang Lin, Lijie...
TACI and endogenous APRIL in B cell maturation - ScienceDirect
WEBAug 1, 2023 · Show more. Add to Mendeley. Share. https://doi.org/10.1016/j.clim.2023.109689 Get rights and content. Highlights. •. B cell activation increases the expression of the TACI-short isoform. •. Human B cells express intracytoplasmic BAFF and APRIL. •. Plasma cell differentiation is driven by the …
Total anterior circulation infarct - Wikipedia
WEBTotal anterior circulation infarct (TACI) is a type of cerebral infarction affecting the entire anterior circulation supplying one side of the brain. The anterior circulation is the part that is supplied by the internal carotid artery, as opposed to the posterior circulation, supplied by the vertebral arteries.
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