Search results
TEM-1 is the most commonly encountered beta-lactamase in Gram-negative bacteria. Up to 90% of ampicillin resistance in E. coli is due to the production of TEM-1. [17] Also responsible for the ampicillin and penicillin resistance that is seen in H. influenzae and N. gonorrhoeae in increasing numbers.
1 lis 2010 · TEM-1 β-lactamase is one of the most well-known antibiotic resistance determinants around. It confers resistance to penicillins and early cephalosporins and has shown an astonishing functional plasticity in response to the introduction of novel drugs derived from these antibiotics.
TEM-1 β-lactamase is a class A enzyme encoded by the bla TEM-1 gene, which is present on the Tn3 transposon [8, 9]. Epidemiological studies have shown TEM-1 to be the most common plasmid-mediated β-lactamase in Gram-negative bacteria [3] .
TEM-1 β-lactamase is one of the most well-known antibiotic resistance determinants around. It confers resistance to penicillins and early cephalosporins and has shown an astonishing functional plasticity in response to the introduction of novel drugs derived from these antibiotics.
Przypisy. Klasyczne beta-laktamazy – są to beta-laktamazy o szerokim spektrum substratowym (są tak także nazywane – nie należy ich mylić z enzymami o poszerzonym spektrum substratowym ). Według klasyfikacji Karen Bush należą one do grupy 2b [1]. Rozkładają penicyliny naturalne, większość ich pochodnych oraz cefalosporyny I generacji.
22 lip 2013 · Using TEM-1 as a model enzyme, we were able to uncover some universal determinants of mutation effects, to quantify how powerful they were to explain the impact of mutations and to define a simple model that could capture both mutation effect and their epistatic interactions.
14 wrz 2018 · Highlights. •. Millisecond H/D exchange can map dynamic modes to the TEM-1 catalytic mechanism. •. Dynamics around Arg244 are linked to a failure to deacylate in TEM-1 inhibitors. •. Cephalosporin resistance can be limited using co-inhibitors that rigidify the 245–257 region. •.
